PD10: Prostate Cancer: Advanced (including Drug Therapy) I
PD10-03: A randomized control study of a prospective questionnaire analysis about the efficacy of smart health after-care including the physical muscle enforced function test in patients with advanced or metastatic prostate cancer who underwent an androgen deprivation test after primary curative therapy
Friday, May 15, 2020
7:00 AM – 9:00 AM
SungHan KIM, Jae Young Joung, Kang Hyun Lee, Mi Kyung Song, Ji Sung Yoo, Seung Hyun Chung
Introduction: This study aimed to prospectively compare and analyze the effects of smart health after-care (SHC) including muscular strength rehabilitation training on quality of life and the psychological and physical aspects of patients with advanced or metastatic prostate cancer who underwent prostatectomy or radiation therapy based on several questionnaires regarding prostate cancer requiring androgen deprivation therapy (ADT).
Methods: Prospectively, 78 patients with prostate cancer who were scheduled to undergo ADT for at least 6 months were included. All patients were instructed to perform aerobic exercise and muscular strength training for the first 12 weeks and then divided into two groups with different exercise protocols for the next 12 weeks under a different protocol established by the Department of Rehabilitation Medicine. In the treatment group, the strength and time of aerobic exercise were prescribed by physiatrists who were different between the two groups based on the patients’ average amount of exercise confirmed through the results of International Physical Activity Questionnaires-Short Form and a 2-minute walking test. The following questionnaires on patients’ symptoms were completed at baseline, 12, and 24 weeks: Ocular Surface Disease Index, Behavioral Activation (BeAct), Hospital Anxiety and Depression Scale (HADS), International Prostatic Symptom Score (IPSS), Functional Assessment of Cancer Therapy-F (FACT-Fatigue), and Mini-Mental State Examination Korean (MMSEK). A one-sample t-test or Wilcoxon signed-rank test was performed according to the satisfaction of normality to test whether the differences between the values obtained at 12 and 24 weeks and baseline were significant.
Results: Of the 78 patients, only 51 patients completed the program until the final 24th week, and only 58 (65.4%) and 68 (74.4%) patients participated until the 12th and 6th weeks. Regarding the IPSS, the quality-of-life scale showed significant improvement after 24 weeks (p=0.009). In the BeAct questionnaire, the work/school life item showed significant differences during the 12th week (p=0.049), but in the 24th week, participants’ questionnaires did not show any significant difference. In addition, there were no significant differences in all items in the HADS questionnaire (p>0.05). The FACT-F questionnaire showed a significant improvement in the quality-of-life item during the 12th week (p=0.030), but not during the 24th week (p=0.640). Significant differences were observed in the MMSEK after 24 weeks (p=0167).
Conclusions: This randomized controlled trial showed that the SHC exercise program improved overall quality of life in terms of urinary disturbance, physical exercise in social life, and fatigue in patients with prostate cancer receiving ADT. Source of
Funding: This research was supported by the National Information Society Agency funded by the Ministry of Science and ICT (Grant number: 2017-0-00902)