MP78-05: ARE TESTOSTERONE LEVELS ASSOCIATED WITH THE DEGREE OF CURVATURE IN MEN WITH PEYRONIE'S DISEASE? FINDINGS FROM A CROSS-SECTIONAL STUDY

Luca Boeri, Paolo Capogrosso, Walter Cazzaniga, Davide Oreggia, Nicolò Schifano, Luigi Candela, Giuseppe Fallara, Federico Belladelli, Edoardo Pozzi, Rayan Matloob, Federico Dehò, Costantino Abbate, Vincenzo Mirone, Francesco Montorsi, Andrea Salonia

Introduction: Previous studies have identified a possible link between Peyronie’s disease (PD)-associated deformity and low testosterone levels (tT). However, the rationale underlying the link between tT and PD severity is unclear. We aimed to evaluate the relationship between serum tT and PD.

Methods: Data of 149 white-European patients presenting for chronic phase PD at a single academic center between 2013 and 2019 were analyzed. All patients were assessed with a comprehensive medical and sexual history. Comorbidities were scored with Charlson Comorbidity Index (CCI). Penile deformity was assessed with an intracavernosal injection-induced rigid erection during a Color Doppler Duplex Ultrasound (CDDU) in every patient. tT was measured in all patients and considered as continuous variable or according to quartiles of the normal range (<3.3, 3.3-4.6, 4.6-6.0, and >6.0 ng/mL). Hypogonadism was defined as tT <3.0 ng/mL. Descriptive statistics and linear regression models tested the association between tT values and the curvature severity.

Results: Overall, median (IQR) age and BMI were 56 (45, 64) years and 25.2 (23.5, 27.7) Kg/m2, respectively. Median tT value was 4.3 (3.3, 6.0) ng/mL in the whole cohort; patients were segregated into tT quartiles as follows; 24.2%, 32.2%, 26.8%, and 16.8%, respectively. Hypogonadism was observed in 21 (4.6%) patients. Median curvature magnitude and plaque size were 45 (30, 70) degrees and 1.5 (1.0, 2.0) cm. Penile curvature was similar between patients with and without hypogonadism (40.0 vs. 45.0 degrees; p=0.69). The magnitude of the curvature was not different according to tT quartiles (p=0.31). As a continuous variable, there was no association between tT levels and the magnitude of the curvature (r= -0.04; p=0.71). At UVA linear regression model, duration of PD was associated with the curvature magnitude (beta 1.1; p=0.02); conversely, age, BMI, CCI, smoking status and tT (beta -0.9; p=0.43) were not. Similar results were observed at MVA linear regression model.

Conclusions: The magnitude of a PD-associated penile curvature is not associated with tT values in patients with chronic phase PD. Source of

Funding: none