Assistant Project Scientist
University of California, Riverside
I am a plant chemical biologist interested in studying the effects of abiotic stress in plants with the help of novel chemical probes. I have been studying how ABA mediates its effects in plants through the Pyrabactin Resistance 1/ PYR1-like/Regulatory component of ABA receptor (RCAR) (PYL) ABA receptors and have discovered several potent and selective chemical probes that aided in the dissection of their function. Recently, we reported an overpowered agonist of ABA action (Opabactin-OP) that is the most potent ABA receptor agonist reported to date, with potent and persistent anti-transpirant effects in several crop species. In our latest work, we have designed an ultrapotent triazole containing ABA receptor antagonist, Antabactin (ANT), based on the OP scaffold which locks the receptors in novel unproductive conformation that prevents binding of phosphatases (PP2C). ANT is much superior to
existing ABA receptor antagonists and exhibits potent antagonism of ABA signaling in vivo.
Thursday, July 30, 2020
3:30 PM – 3:45 PM EDT