Tom Kalil has served for two Presidents (Clinton and Obama) in White House policy-making roles related to science, technology and innovation. Kalil will discuss (1) the role of the “policy entrepreneur” in identifying, designing, launching and expanding national S&T initiatives; (2) the origins of new ideas; (3) tools that policy entrepreneurs have at their disposal to promote change; and (4) the relevance of policy entrepreneurs to scientific societies such as the ASPB.