Despite a lot of academic research claiming to make satisfactory adhesives out of oilseed proteins, only a couple of routes have been commercialized as wood adhesives. This leads to the question of what factors influence the design of a water-resistant wood adhesive. Certainly the structure of the protein is a critical factor that leads to an adhesive that coalesce into a strong film after rewetting. The comparison of proteins to poly(vinyl acetate) provides an interesting model. This depends upon what is meant by and results from denaturation and agglomeration. The wood bond strength for various tests for oilseed adhesives are compared to the current model for protein adhesives.