This seminar provides in-depth information to enable equine surgeons to achieve the best outcomes with their neonatal soft-tissue patients. The first portion of the seminar focuses on the perioperative management of critical neonatal patients and provides practical strategies to stabilize, optimize surgical timing, and improve recovery in these patients. The second portion of the seminar provides in-depth knowledge from experienced surgeons. The first section discusses specific advanced gastrointestinal surgical techniques and methods to optimize the outcomes of gastrointestinal surgeries based upon experience in private practice with a high -volume foal caseload. The second section highlights indications and surgical techniques to perform nephrectomies in the foal, a challenging urogenital procedure.