Transcriptomic Meta-analysis Reveals a Core Transcriptional Program in Murine B Cell Anergy and Implicates Immunometabolic Regulation as a Central Pathway in Maintaining Non-responsiveness of Autoreactive B-cells in Both Mouse and Man Isaac Harley, MD, PhD – University of Colorado Anschutz Medical Campus
10:10 AM – 10:20 AM ET
A First in Class Therapeutic Nanoparticle for Specific Targeting of Anti-citrullinated Protein Antibody Ameliorates Serum Transfer and Collagen Induced Arthritis Kira Astakhova, PhD – DTU
10:20 AM – 10:30 AM ET
B Cell-specific TLR7 Regulates Lupus in TLR9 Deficient Mice Haylee Baxendell, BS – University of Pittsburgh
10:30 AM – 10:40 AM ET
Functional Characterization of PLCG2 Mutations Found in Subjects with Autoinflammation and PLCG2-Associated Antibody Deficiency and Immune Dysregulation (APLAID) Reveals Both Hypermorphic and Hypomorphic Mutants Kathleen C. Baysac, PhD – NIAMS, NIH
10:40 AM – 10:50 AM ET
Exploring the RA Bone Marrow Niche by Single-cell Technology to Identify Long Lived ACPA+ Plasma Cells Caroline Grönwall, PhD – Karolinska Institutet
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