Pediatric COVID-19 Hyper-Inflammation: Decipher Clues & Enhance Collaborations

Moderator(s)

• 

  Tamar Rubinstein, MD, MS

  Albert Einstein College of Medicine

Speaker(s)

• 

  Angelo Ravelli, MD

  Istituto Giannina Gaslini, Genoa, Italy
• 

  Mary Beth Son, MD

  Boston Children's Hospital

How can pediatric rheumatologists worldwide develop viable channels for collaboration to tackle the known and yet-to-be-known complications of COVID-19 infection in children? A small but growing population of children and teens infected with COVID-19 develop severe multisystem inflammatory syndrome in children (MIS-C), also called pediatric inflammatory multisystem syndrome (PIMS), a condition similar to Kawasaki disease or a toxic-shock-like syndrome. In this exciting session, experts from Italy, Canada and the United States will share their first-hand experiences with these mysterious COVID-associated inflammatory syndromes in pediatric patients. Talks will explore potential disease mechanisms that offer important clues to managing these conditions in young patients.

Learning Objectives:

• Describe the experiences with COVID-associated inflammation in Italy, Europe and other countries outside the USA
• Discuss the potential mechanisms to explain both Kawasaki disease and toxic-shock-like phenotypes in MIS-C/PIMS
• Describe experiences with COVID-associated inflammation in the USA and Canada
• Utilize existing ACR MIS-C guidelines in the diagnosis and treatment of children with COVID-associated inflammation

Presentations:

• 4:00 PM – 4:20 PM ET

  International Perspectives and Proposed Pathophysiology of MIS-C
  Angelo Ravelli, MD – Istituto Giannina Gaslini, Genoa, Italy
• 4:20 PM – 4:40 PM ET

  MIS-C: What Have We Learned and What Challenges Await?
  Mary Beth Son, MD – Boston Children's Hospital
• 4:40 PM – 5:00 PM ET

  Q&A