Autoimmunity in Immunodeficiency

Moderator(s)

• 

  Leonard Calabrese, DO

  Cleveland Clinic

Speaker(s)

• CC

  Charlotte Cunningham-Rundles, MD, PhD

  Icahn School of Medicine at Mount Sinai
• 

  Jonathan Miner, MD, PhD

  Washington University in Saint Louis, Division of Infectious Diseases

Patients with immunodeficiencies can present with autoimmune or inflammatory manifestations. The overall goals of this session are to highlight the overlap between immunodeficiencies and autoimmune conditions, and to discuss mechanisms that may underlie this predilection for breaks in tolerance. Faculty will provide specific examples of immune dysregulation that may induce both immunodeficiency and autoimmunity. They will share practical considerations for when and how to evaluate for immune deficiency in patients with inflammatory rheumatic presentations.

Learning Objectives:

• Explain why immunodeficiencies may have a range of autoimmune manifestations
• Discuss mechanisms that may lead to both immunodeficiency and autoimmunity
• Describe considerations for when and how to evaluate for immune deficiency in patients with inflammatory rheumatic presentations

Presentations:

• 3:00 PM – 3:15 PM ET

  Primary Immune Deficiency & Autoimmunity: Learning from Our Patients
  Charlotte Cunningham-Rundles, MD, PhD – Icahn School of Medicine at Mount Sinai
• 3:15 PM – 3:30 PM ET

  Mechanisms of Lung Disease, Autoimmunity & Immunodeficiency in Models of STING-Associated Vasculopathy
  Jonathan Miner, MD, PhD – Washington University in Saint Louis, Division of Infectious Diseases
• 3:30 PM – 3:45 PM ET

  Q&A