Rheumatoid arthritis (RA)
Autoimmune disorders, such as rheumatoid arthritis, arise in genetically predisposed individuals through contributions from genetic, stochastic and environmental factors. Mounting evidence has implicated the impact of an imbalanced gut microbiome in pathogenesis. At this session, faculty will provide an overview on current understanding of how our gut microbial communities contribute to immune development and regulation, and how imbalances in the gut microbiota, termed dysbiosis, are common in patients with seropositive rheumatoid arthritis. But are these correlated changes truly causative? Current progress will be discussed in efforts to implement a practical dietary intervention, based on critical review of the literature on anti-inflammatory dietary interventions, which is designed to restore balance in the gut microbiome and diet- related circulating metabolites, and test whether there will be associated clinical disease activity.