David Mossad, MD1, Will Aurand, DO2, Ronald J. Markert, PhD3, Padmini Krishnamurthy, MD1; 1Wright State University, Boonshoft School of Medicine, Dayton, OH; 2Wright State University, Dayton, OH; 3Boonshoft School of Medicine, Dayton, OH
Introduction: The incidence of colorectal cancer (CRC) in patients less than 50 years of age has increased in recent years. Previous research has led to creation of different screening guidelines for certain populations (e.g., lower age for African Americans [AA]). This study examines demographics for CRC patients over time periods in the United States. Methods: The National Hospital Discharge Survey and the National Hospital/Ambulatory Medical Care Survey were queried from 2001-2015 to identify patients with an ICD-9 code for CRC. Five-year time periods were used to compare trends for age, sex, and region among CRC patients. Also, patients age 40-50 vs >50 years old were compared on sex, race, and region. SPSS was used for chi-square analysis and the least significant difference post hoc test for one-way analysis of variance. Inferences were at the 0.05 level of significance. Results: Among 19,214 CRC patients, 10,819 were diagnosed in the 2001-2005 period, 7,870 in the 2006-2010 period, and 525 in the 2011-2015 period. The 40-50 age group included 1,762 patients while the >50 age group included 16,968 patients. The mean age of CRC diagnosis decreased linearly from 2001-2005 (68.78 yrs.) to 2006-2010 (67.55 yrs.) and 2011-2015 (64.05 yrs.) (p< 0.001) (Fig. 1). The proportion of patients in the 40-50 age group increased for the three time periods (8.7% vs 10.2% vs 11.9%) (p < 0.001) (Fig. 2). When taking all cases into account, gender of CRC patients did not differ over the three time periods (50.6%, 50.0% and 53.5% female respectively). There was a decrease in the proportion of patients diagnosed in the Northeast over time (25.9% vs 22.7% vs 13.6%) while increases were observed in the South (33.5% vs 39% vs 40.2%) and the West (11.2% vs 9.8% vs 19.7%) (p< 0.001). The Midwest maintained similar rates (29.3% vs 28.5% vs 26.4%). Compared to >50 age group, the 40-50 age group had a higher proportion of males ( 52.5% Vs 49.2%, p=0.004 ), higher proportion of AA (11.6% Vs 16.0%, p< 0.001)), lower proportion of Caucasians ( 52.5% Vs 57.3% p< 0.001) , more likely to be from the South ( 42.2% Vs 35.0% p< 0.001) and less likely to be from Midwest ( 23.6% Vs 29.7% p< 0.001). Discussion: Over time periods, the mean age of CRC patients has decreased. Concurrently, the proportion of patients diagnosed at age 50 or younger increased. Further, the 40-50 age group had a higher proportion of AAs and males. These trends lend further support for consideration of adjustments and individualization in screening guidelines.
Mean age of CRC diagnosis over time (p<0.001)
Proportion of CRC patients age 40-50 over time (p<0.001)
Disclosures: David Mossad indicated no relevant financial relationships. Will Aurand indicated no relevant financial relationships. Ronald Markert indicated no relevant financial relationships. Padmini Krishnamurthy indicated no relevant financial relationships.