University of California Davis
Ian E. Brown MD, PhD, is an Assistant Professor of Surgery at the University of California, Davis. He has two two primary research interests. The first is in understanding the intersection between coagulation and inflammation in the setting of acute severe trauma and how this interplay impacts outcomes through consequences of coagulopathy and endotheliopathy.The second focus is on social determinats of violence-related trauma recidivism and how hospital-based violence intervention programs (HVIP) such as the UC Davis Wraparound HVIP can disrupt cycles of violence through trauma-informed, culturally competent interventions.
His lab uses a murine blunt thoracic trauma model to investigate the role of cell-adhesion molecules such as P-selectin in inflammatory processes and intravascular thromboembolic injury such as pulmonary arterial thrombosis (PAT) in the setting of trauma. Through understanding the natural history of PAT and the role and regulation of P-selectin, the goal is to determine the necessity of intervention and to investigate the efficacy of P-selectin blockade as an alternative to anti-coagulation for intervention. More broadly, cell adhesion molecules such as P-selectin likely play a role in thrombosis in the setting of vascular injury, vascular repair, injuries of ischemia and reperfusion, and potentially in the setting of infection and sepsis. Understanding the biology of cell adhesion molecules such as P-selectin may therefore contribute to the continuing evolution of resuscitation paradigms that improve trauma-associated outcomes.
In working with the Wraparound HVIP, he evaluates the effectiveness of a public health oriented, trauma-informed approach of relationship-based mentoring, culturally affirming case management, and partnerships with natural and community supports to facilitate holistic recovery from violent injury and reduce the risk for future violence involvement. A mixed methods approach with quantitative and qualitative data analysis is used to understand the social determinants that contribute to violence-related trauma and to evaluate the impact and efficacy of interventions.
Wednesday, September 9, 2020
2:40 PM – 3:00 PM