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(1236) Staphylococcus aureus Surgical Site Infection – Epidemiology in Europe (SALT)


Authors:

Sibylle Mellinghoff, MD – Dr., 1University Hospital of Cologne, Cologne, Germany; 2CECAD, Medical Faculty, University of Cologne, Germany; 3DZIF, partner site Bonn-Cologne, Germany

Caroline Bruns, PhD – PhD, University Hospital of Cologne, Cologne, Germany; CECAD, Medical Faculty, University of Cologne, Germany; DZIF, partner site Bonn-Cologne, Germany

Markus Albertrsmeier, Prof – Prof, 4Hospital of the University of Munich, Munich, Germany

Matteo Bassetti, Prof – Prof, 5University of Udine and Azienda Sanitaria Universitaria Integrata, Udine, Italy

Juan Horcajada, MD, PhD – Doctor, Hospital del Mar

J Janne Vehreschild, MD – Prof. Dr. med., University Hospital of Frankfurt

Blasius Liss, Dr – Dr, HELIOS University Hospital of Wuppertal, Wuppertal, Germany;

Oliver Cornely, Prof. – Prof., University of Cologne, Faculty of Medicine and University Hospital Cologne


Co-Authors:

Presenting Author: Sibylle Mellinghoff, MD – Dr., 1University Hospital of Cologne, Cologne, Germany; 2CECAD, Medical Faculty, University of Cologne, Germany; 3DZIF, partner site Bonn-Cologne, Germany
Co-Author: Caroline Bruns, PhD – PhD, University Hospital of Cologne, Cologne, Germany; CECAD, Medical Faculty, University of Cologne, Germany; DZIF, partner site Bonn-Cologne, Germany
Co-Author: Markus Albertrsmeier, Prof – Prof, 4Hospital of the University of Munich, Munich, Germany
Co-Author: Matteo Bassetti, Prof – Prof, 5University of Udine and Azienda Sanitaria Universitaria Integrata, Udine, Italy
Co-Author: Juan Horcajada, MD, PhD – Doctor, Hospital del Mar
Co-Author: J Janne Vehreschild, MD – Prof. Dr. med., University Hospital of Frankfurt
Co-Author: Blasius Liss, Dr – Dr, HELIOS University Hospital of Wuppertal, Wuppertal, Germany;
Co-Author: Oliver Cornely, Prof. – Prof., University of Cologne, Faculty of Medicine and University Hospital Cologne

Abstract:

Background :

We conduct a retrospective, multinational cohort study with a nested case-control (NCT03353532). Data from all patients undergoing any surgical procedure in 2016 are collected within the cohort, comprising more than 150,000 procedures. S. aureus SSI cases are documented in an electronic database and matched 1:1 to controls within each center. Criteria for matching include epidemiological data and type of procedure. Participating sites are 14 major surgical centers in France, Germany, Italy, Spain, and the United Kingdom. We here present preliminary data from the interim analysis.


Methods :

We conduct a retrospective, multinational cohort study with a nested case-control (NCT03353532). Data from all patients undergoing any surgical procedure in 2016 are collected within the cohort, comprising more than 150,000 procedures. S. aureus SSI cases are documented in an electronic database and matched 1:1 to controls within each center. Criteria for matching include epidemiological data and type of procedure. Participating sites are 14 major surgical centers in France, Germany, Italy, Spain, and the United Kingdom. We here present preliminary data from the interim analysis.


Results :

We determine overall and procedure specific incidence of S. aureus SSI. To date, 619 cases have been documented with a mean age of 59,0 years, 50,7% male and 49,3% female. Chronic cardiovascular disease (23%), diabetes (22%) and solid tumors (18%) are the most frequent comorbidities. Overall length of hospitalization is 19 days. A total of 20% SSI cases were treated at the intensive care unit, 49% were readmitted to the hospital, and 47% patients needed revision surgery.


Conclusion :

The study includes all surgical procedures at participating centers allowing us to determine the incidence for all common surgical procedures aiming to better understand the risk of certain procedures. Furthermore, the study will analyze the risk composition of the surgical patient population to enable the calculation of the number of patients at risk in the overall surgical population in Europe. Predictive factors for S. aureus SSIwill be analyzed and thus allow future investigation into targeted prophylactic strategies such as S. aureus vaccines.





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