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3D Bio-Printed Scaffold for Bone Augmentation


Authors:

Blake Adams, DDS – Resident, Loma Linda University

Sam Souza, DDS – Resident, Loma Linda University

Abstract:

Purpose of the Study: Evaluate the ability of 3D bio-printed PCL scaffolds to allow bone formation within the created defects and access the accuracy of these printed scaffolds within the created defects.

Methods: A total of 5 New Zealand white rabbits were used for this study. One rabbit was used to calibrate and test the surgical procedure prior to the involvement of the remaining 4 rabbits. Using cone beam computed tomography (CBCT) a defect was digitally created and a surgical guide fabricated to ensure all defects were the same in the right and left tibia. A PCL scaffold was then designed anad 3D bio-printed to fill the defect for augmentation. Each animal was then sedated under general anesthesia and surgical exposure of both tibia's was performed. Two identical defects were then created with the use of the surgical guide. The defect on the right tibia served as the control in this study with the tibia on the left as the test site. Bio-printed PCL scaffolds were then placed in the defects and stabilized within the left tibia with two titanium screws. On the control (right) side, a mixture of autogenous bone and xenograft were placed in the defect and covered with a resorbable membrane and secured with 4 tacks. The grafted sites were closed and allowed to heal for 16 weeks prior to euthanasia for resection of both the test and control bones for microCT and histologic analysis.

Results: Results will be presented at the meeting

Conclusion: Conclusion will be presented at the meeting

Articles: 1. Fahmy MD, Jazayeri HE, Razavi M, Masri R, Tayebi L. Three‚ÄźDimensional Bioprinting Materials with Potential Application in Preprosthetic Surgery. Journal of Prosthodontics. 2016 Feb 1. 2. Green DW, Lee JS, Jung HS. Small-Scale Fabrication of Biomimetic Structures for Periodontal Regeneration. Frontiers in physiology. 2016;7 3. Barabaschi GD, Manoharan V, Li Q, Bertassoni LE. Engineering pre-vascularized scaffolds for bone regeneration. InEngineering Mineralized and Load Bearing Tissues 2015 (pp. 79-94). Springer International Publishing. 4. Dodziuk H. Applications of 3D printing in healthcare. Kardiochirurgia i Torakochirurgia Polska. 2016 Sep;13(3):283-93. 5. Ferreira JN, Rungarunlert S, Urkasemsin G, Adine C, Souza GR. Three-Dimensional Bioprinting Nanotechnologies towards Clinical Application of Stem Cells and Their Secretome in Salivary Gland Regeneration. Stem Cells International. 2016 Dec 20;2016 6. Hung BP, Naved BA, Nyberg EL, Dias M, Holmes CA, Elisseeff JH, Dorafshar AH, Grayson WL. Three-dimensional printing of bone extracellular matrix for craniofacial regeneration. ACS biomaterials science & engineering. 2016 May 2;2(10):1806-16.

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