Category: Fellows Posters
Purpose: The objective of this study is to assess the effect of etomidate on hospital mortality in patients with sepsis or septic shock who received etomidate for induction for mechanical ventilation.
Methods: This study will be submitted to the Institutional Review Board for approval. The electronic medical record will identify patients who are more than 19 years of age who were admitted with diagnosis codes for sepsis or septic shock who received either etomidate or standard of care sedation and had a procedure code for intubation. Patients will be excluded if they had a contraindication to etomidate or standard of care sedation and intubation prior to surgery. The data will cover September 1st 2017 through September 30th, 2019. Data that will be collected will include age, sequential organ failure assessment score, lactic acid level, total dose of etomidate and standard of care sedation, comorbidities, steroid administration, hospital mortality, intensive care unit length of stay, hospital length of stay, mechanical ventilator days, hypotension, vasopressor free days, fluids, sepsis, and septic shock. The primary outcome will assess in hospital mortality in patients who received either etomidate or standard of care sedation for induction for mechanical ventilation who had a sepsis or septic shock diagnosis. Secondary outcomes will include hospital length of stay, mechanical ventilator days, intensive care unity length of stay, and vasopressor free days. Patients will be stratified by sequential organ failure assessment score that will be collected using the worst values in a 24 hour period post etomidate or standard of care sedation administration.