Category: Fellows Posters
Purpose: The aim of the study is to identify risk factors that lead to Clostridium difficile infection, also known as Clostridioides difficile, in order to reduce future infection rates through stewardship efforts. Current guidelines recommend finding hospital-specific risk factors based on local patient populations. This study will be carried out by conducting chart reviews on patients who tested positive for Clostridium difficile infection in order to identify these risk factors.
Methods: This study is a multi-center, retrospective chart review. Information will be collected on all patients ≥ 18 years old, with a confirmed Clostridium difficile infection diagnosis at CHI St. Vincent facilities during January 2016 through June 2019. An electronic surveillance system will be used to identify Clostridium difficile positive stool samples. The primary endpoint is to identify hospital-specific antibiotic-related risk factors associated with Clostridium difficile incidence. These include type and number of antibiotic(s), indication, cumulative doses, and duration of therapy. Secondary endpoints include review of other risk factors associated with C. diff infection such as PPI use, hospital location, month/year of diagnosis, duration of hospitalization, long term care facility/nursing home transfers, age, sex, comorbidities, hospital acquired (HA) vs community acquired (CA). Risk factors will be collected from an electronic health record. Continuous variables will be analyzed using standard deviation and student t-test. Categorical variables will be reported as number/percentage of population and Chi-square test, Fisher Exact test, and analysis of variance will be used where appropriate. P values of ≤0.05 will be considered statistically significant for differences detected between correlations. Confidence intervals of 95% will be used to demonstrate the magnitude of difference between variables compared where appropriate. This study has been submitted to the Institutional Review Board for approval.