Category: Professional Posters
Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used drugs worldwide. Nevertheless, they carry several side effects such as gastrointestinal mucosal damage, renal toxicity, and cardiovascular side effects. Aiming to find a novel analgesic/anti-inflammatory drug with minimal side effects, the present study was designed to screen and evaluate some newly synthesized molecules.
Methods: Mice weighing 20 to 25 g were used to determine the efficacy of the newly synthesized compounds. Anti-inflammatory effect of the investigated compounds was assessed using carrageenan-induced paw edema. Tail flick and hot plate tests were used to evaluate the analgesic effects. Data were analyzed using SPSS version 20.
Results: Out of 17 compounds, 6 showed a statistical significant anti-inflammatory effect as compared to the control group. In the tail flick test, 5 compounds showed a significant increase in latency time as compared to the control. Results were even better than indomethacin and celecoxib groups. Hot plate test confirmed the results obtained in the tail flick test.
Conclusion: The compounds possessing anti-inflammatory and analgesic effects constitute a potential molecules for further studies