7th Annual Gulf-Atlantic Veterinary Conference
Immune-mediated diseases are commonly recognized in veterinary medicine with the use of immunosuppressant drugs becoming more common. Medical suppression of ongoing damage by immune system is the mainstay of therapy with drugs and immunosuppressive protocols adopted from human medicine. Empirical application of immunosuppressants without a firm emphasis on supporting literature is normal in veterinary patients. Before prescribing immunosuppressants, the indication and effectiveness of the immunosuppressant, the formulation, affordability, safety, required monitoring, handling, known drug interactions and side effects should be considered. Monitoring is also an important aspect of immunosuppressant use. In this lecture, we'll establish what are “traditional” immunosuppressants (corticosteroids, azathioprine, chlorambucil, cyclophosphamide and vincristine), as well as newer agents (cyclosporin, mycophenolate and leflunomide). Specific focus will be on the use of combination therapy and mode of action of each drug.