Assessment of the seismic resilience of communities requires modeling the interactions that take place between the multiple systems of society, including engineering, economic, social, financial, environmental, political, and others. The complex interdependencies that arise between these systems is challenging to model because of the multi-disciplinary nature of the problem and range of temporal and spatial scales involved. With this motivation, a fully scalable and adaptable distributed computing framework is developed for modeling the seismic resilience of communities. The framework includes different simulators, each of which represents various aspects of the problem, such city layout, regional seismic ground motions, structural response, structural and non-structural damage and loss assessment. Each simulator is implemented as a black box that can communicate with any other simulator through two-way interactions managed by a specially developed run-time infrastructure (RTI) software. The proposed framework is demonstrated through a case study that is focused on modeling the resilience of an archetype community facing a seismic hazard.