This presentation will highlight recent research on the performance, design, and manufacturing of structural insulated panels, commonly known as SIPs, for loadbearing walls. SIPs are a panelized building system composed of external facer panels, such as oriented strandboard (OSB) sheets, bonded to a lightweight foam core. As the demand for SIP panels increases as an alternative to light frame construction in residential and light-commercial buildings, so too does the need for comprehensive code requirements to satisfy regulatory agencies and building officials. This presentation will describe a combined experimental and analytical study whose objective was to investigate the structural behavior of OSB-faced SIPs subject to short-term axial loads. An overview of the results of 53 full-sized panel tests, conducted with varied types of foam core, thickness, and construction detailing subjected to concentric and eccentric axial loads, will be discussed. The observed relationship between panel parameters and axial strength was used to calibrate a reliability-based design expression to predict the load carrying capacity of full-size panels based on a small number of confirmatory tests. In addition, several practical design recommendations for panel design and construction are proposed to improve the performance of axially loaded SIPs for use as walls in low- and mid-rise wood buildings. The results also highlight the importance of maintaining adequate bond between the foam and OSB facers, and the need for manufacturers to develop quality control practices to assess bond level throughout production. The scope of the presentation will address practical issues related to SIPs to engage practitioners from the construction industry, manufacturing, and academia.