Data Analysis and Informatics
The National Cancer Institute (NCI) supports, among many initiatives, the Cancer Target Discovery and Development (CTD2) Network, which currently comprises 12 Centers nationwide. The primary goal of the Network is “to bridge the knowledge gap between large-scale genomic datasets and the underlying etiology of cancer development, progression, and/or metastasis”. To make progress toward this ambitious goal, member Centers of the Network are necessarily quite diverse in their biological specialties, experimental methods, and informatic or computational sophistication.
To encourage sharing and re-use of data between member Centers, and data dissemination to the wider cancer research community, the CTD2 Network has evolved an interconnected ecosystem of web-based tools and data services, including the CTD2 Dashboard, CTD2 Data Portal, and several investigator-initiated web-based resources. Each of these resources serves distinct purposes and audiences, and accordingly requires different compromises to implement and different processes to maintain. I will provide an overview of these resources, lessons learned during their evolution, and prospects for future data integration within and beyond the CTD2 Network.