Focus Session
SCMR 22nd Annual Scientific Sessions
Jingwen Dai, MD
Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science
Jian Cao, MD
Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science,Beijing,China
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science
Lu Lin, MD
Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Jing An, PhD
Siemens Healthcare, MR Collaborations NE Asia, Beijing, China
Siemens Healthcare, MR Collaborations NE Asia, Beijing, China
Michaela Schmidt, RT
Siemens Healthcare GmbH, Erlangen, Germany
SIEMENS HEALTHCARE GmbH
Christoph Forman, PhD
Siemens Healthcare GmbH, Erlangen, Germany
SIEMENS HEALTHCARE GmbH
Yining Wang, MD
Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Zhengyu Jin
Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China
Background:
Coronary magnetic resonance angiography (MRA) is a promising noninvasive technique for evaluating coronary artery disease (CAD) which is radiation-free and not affected by severe calcification artifacts. However, clinical feasibility of coronary MRA is still limited by long acquisition time and motion artifacts. Compressed sensing (CS) with sparse sampling and iterative reconstruction can effectively reduce acquisition time. For coronary MRA scans, shortening acquisition time also reduces the chance of heart rate and respiratory pattern variations, so it will finally increase the image quality. The aim of this study was to evaluate the diagnostic performance of contrast-enhanced CS coronary MRA in the detection of clinically significant coronary artery stenosis by using CTA as a reference.
Methods:
13 consecutive patients with clinically suspected CAD underwent contrast-enhanced CS coronary MRA followed by a CTA scan. All contrast-enhanced CS coronary MRA data were acquired on a 3T MR scanner (MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany). The key parameters were as follows: TR/TE = 4/1.7ms, T2 prep.duration=50ms, FA=20deg, bandwidth=401Hz/Px, voxel size=1.1 x 1.1 x 1.1 mm3,acceleration factor 10.21. The quality of the contrast-enhanced CS MRA image was graded for each segment on a four-point scale (1: poor, 2: fair, 3: good; 4: excellent). All the segments with quality scores 2–4 were assessed to identify significant narrowing (≥50% lumen diameter reduction) in comparison with CTA. The inter-modality agreement between MRA and CTA evaluation of coronary artery stenosis was assessed using a Kappa test. SPSS (version 20, IBM, America) was used for data analysis.
Results:
All 13 patients underwent contrast-enhanced CS MRA successfully with the mean heart rate 66±11 beats per minute. The average imaging time was 6.0±1.5 minutes. Among 117 segments in total, 110 (94.0%) segments had a diagnostic image quality and were included in the analysis. The inter-modality evaluation between MRA and CTA was 0.722 (p＜0.01), representing good agreement for assessment of stenosis.
Conclusion:
Contrast-enhanced CS whole-heart coronary 3T MR angiography is a promising noninvasive technique for detecting clinically significant coronary stenosis. CS also successfully makes MRA acquisition time short enough and could be applied in the waiting time between contrast injection and late gadolinium enhancement imaging.