Envision a network where institutions can ubiquitously submit their research to other institutions and maintain a level of local review. This vision is now a reality: introducing the SkyiRIS Research Network. This module allows institutions to link their research databases to a collaborative network. What makes SkyiRIS standout is that it promotes collaboration between institutions involved in multi-site research and allows internal/external communication between research teams and the review board without limiting the system functionality to a document review process. It behaves and works with the complete functionality of a robust eIRB system, specifically SMART forms and workflows. One of the primary benefits of the SkyiRIS Research Network’s system to system feature is that it enables institutions to perform local review on other regulatory processes that are not handled by the remote affiliate such as Conflict of Interest, Radiation Safety, Bio Safety, Environmental Safety, Feasibility, etc.