Many EM investigators are intimidated by the prospect of conducting research with a “Waiver of Informed Consent” (WIC) for study participants. However, a host of conditions that EM researchers should be investigating are not conducive to obtaining informed consent from study participants, due to the subject’s compromised physical and/or mental state. Regulatory guidelines on how to perform WIC studies are vague and hard to interpret, with many of the community outreach requirements of WIC deferred to local IRBs. These factors combine to make the development, IRB-approval, and execution of WIC studies difficult to achieve, even for experienced EM researchers. Consequently, this session will leverage the knowledge and experience of seasoned WIC EM researchers to help the rest of us understand exactly how EM research can be done using WIC. Special attention will be paid to the elements of WIC studies that differ from other forms of clinical EM research, including the PI’s ethical obligations to subjects, the community outreach process, and how to navigate the path to IRB approval.