Mentoring over the academic research career lifecycle has many common elements, but mentee needs evolve as junior investigators progress through their personal and professional lives. Mentoring of medical students, trainees, and junior faculty needs to be career- and life-stage dependent as well as iterative. Mentoring should mirror the progressive nature of research skills training. It should match not only the mentee’s needs for that stage, but also help prepare the mentee for subsequent research career stages. In this session, four emergency medicine clinician-scientists with National Institutes of Health (NIH) mid-career K24 mentoring awards will present mentoring strategies and approaches applicable for the academic research career lifecycle. The four NIH K24 awardees have extensive experience in mentoring junior investigators at all training levels on research projects, training, and career development. They review the responsibilities of both mentees and mentors and will offer tips and advice for mentees on what they should seek at each career development stage. They also will advise mentors on the techniques, approaches, and strategies that benefit mentees at each stage. They will also propose milestones for each career development stage and review training opportunities commensurate with that stage. The session will conclude with an audience and panel discussion on suggested approaches to bring mentees to that turning point where successful academic careers begin.