In 2017, the West Virginia Department of Health and Human Resources partnered with the West Virginia University Injury Control Research Center to conduct a state-level naloxone distribution project. Funds leveraged from the Substance Abuse and Mental Health Services Administration to purchase naloxone, kit materials, supplies, and equipment were braided with funds from the Centers for Disease Control and Prevention (CDC) to cover staff and administrative costs required to plan, carry out, and evaluate the effort, resulting in a “Rapid Response Project” under the CDC-funded West Virginia Prevention for States award. Following acquisition and assembly of naloxone kit components, compilation of a list that included existing naloxone programs and organizations interested in starting programs, and assessment of risk and naloxone need among all listed organizations, 8,250 two-dose naloxone rescue kits were provided to 87 organizations in 38 of 55 West Virginia counties. These included non-EMS first response agencies (n = 24), organizations with existing or new take-home naloxone programs (n= 42), and other organizations (n = 21). Both qualitative and quantitative findings from the program evaluation will be presented, including the findings from an interrupted time series analysis.