Formulation and Quality
2019 PharmSci 360
Spray-drying has gained significant momentum in recent years in the development of amorphous solid dispersions (ASD) to address API solubility and bioavailability challenges exhibited in the development of new drugs.
Systematic screening methods to identify the best miscible polymers and API combinations while conserving the consumption of active material will be presented. Critical processing parameters for controlling spray-dried particle morphology and size will be reviewed together with supporting case studies. Following a structured approach allows for a fast track in the development of ASD products.