Formulation and Quality
2019 PharmSci 360
Dry powder inhalers are frequently used for dosing of drugs into the lungs. Various techniques for the formulations are used. Traditionally inhaled powders are designed on the carrier principle. For the carrier principle, the API is micronized or nano-crystallized and mixed together with a carrier. The control on the processability is coming from the flow of the excipient. The drug deposition is for capsule and blister devise related to the fine excipient particles. Carriers are mostly selected from sugars and the most common carrier is lactose. For higher dose formulations the micronization in combination with the carrier principle is not achievable anymore. Other techniques like spraydrying, freezedrying or complexations with excipients will be used to produce low dense particles with a low aerodynamic particle size. For the production of these particles other functionalities are required. An overview will be given on the required functionalities and the excipients that will contribute to these functionalities.