Manufacturing and Bioprocessing
2019 PharmSci 360
A number of pharmaceutical chemicals are packaged in amber glass bottles to prevent oxidation by UV light. The amber glass resulting from the addition of iron, sulfur and carbon to silica can emit fluorescence when exposed to Raman excitation light source. This poster will describe how spatially offset Raman spectroscopy mitigates this undesirable deexcitation phenomenon to enable the interrogation of a material inside an amber glass container. Polysorbates 20 and 80 in amber bottles will be used to illustrate the effect of undesired fluorescence. A comparison between spatially offset Raman spectroscopy and conventional backscattering Raman spectroscopy will be also performed to emphasize the importance of fluorescence subtraction or elimination to limit or eliminate erroneous results during mandated identification test performed at the reception of raw materials for use in the manufacturing of drug products.