Formulation and Quality – Biomolecular
2019 PharmSci 360
Gonorrhea is one of the most common sexually transmitted disease, caused by Gram negative diplococcus bacteria, Nisseria gonorrhoeae. Currently there are no vaccines for Gonorrhea. Therefore, there is an urgent need for a vaccine. An effective and patient compliant option could be a film dosage form of the vaccine for buccal or sublingual administration. Film dosage forms are easy to prepare, cost effective, and patient complaint. When films are administered in buccal or sublingual area, the vaccines are absorbed systematically. The systemic route can avoid the first pass effect and can increase the bioavailability of the vaccines. The film can be designed is in multilayer forms, where the outer layer can be a protective layer which can prevent the destruction or swallowing of the vaccine. Additionally, it is possible to use vaccines in particulate form. Another advantage of the film is that it also can be used for local administration.