Formulation and Quality – Chemical
2019 PharmSci 360
This presentation highlights the development of a computational model that simulates the powder dispersion process from a capsule in a dry powder inhaler (DPI) and its subsequent use for studying the factors that lead to in-capsule and in-device powder retention after each device use. Specifically, air flow into the capsule and the dome shape of the capsule ends cause a small amount of powder to be inevitably retained within the capsule. In addition, flow stagnation points resulting from the DPI design and powder-device adhesion lead to powder being retained at specific locations within the device. The predicted location and approximate quantity of powder retention are found to be in reasonable agreement with experimental data. In-silico parametric studies identified drug product attributes and device design features critical to powder retention and device performance, therefore providing insights into how the two may be optimized to minimize the former and maximize the latter.