Bioanalytics – Biomolecular
2019 PharmSci 360
Determination of an individual’s skeletal maturation status is clinically important for the diagnosis and treatment planning of orthodontic patients. An X-ray image of the craniofacial skeleton determining cervical vertebral maturation stages (CVMS) is routinely used by orthodontists. Yet, CVMS reliability is questionable and limited with subjective observation and staging. CVMS also lacks the ability to determine the intensity and cessation of growth spurt of an individual. Bio-markers such as insulin-like growth factor-1 (IGF-1), estradiol and testosterone play a key role in regulating puberty, growth spurt and skeletal maturation. The purpose of this study was to find correlation/association of salivary IGF-1, estradiol and testosterone with CVMS generated via cone beam computed tomography. Secondary objective of this study was to correlate age, height and weight of the patient with CVMS. A cross-sectional clinical research was conducted with IRB approval that included patients from Roseman University of Health Sciences Orthodontic Clinic.