Manufacturing and Bioprocessing
2019 PharmSci 360
Encrustation is an uncontrolled crystallization that can happen on reactor walls, surface of PAT probes, sensors, and other areas of a crystallizer prompting several operational issues such as obstructing fluid flow and increasing thermal resistance. This is a risk factor that can cause product and process failure in continuous crystallization processes. Various risk mitigation strategies proposed in the literature, such as crystallizer wall coating, use of additives to control encrustation kinetics, and periodic steady state operation show promising results in delaying or prevention of encrustation. It is important to further understand this risk factor due to increased interest in the use of continuous crystallization in industrial applications.