Formulation and Quality – Chemical
2019 PharmSci 360
In Joshi Capsule drug delivery system, the drug is incorporated in the capsule shell matrix. Vitamin B12 is used as the model drug. The concept of orally dissolving capsule (ODC) has also been adopted in this system. The capsule dissolves slowly in the mouth cavity allowing a slow release of B12 and thereby enabling vitamin B12 to be available for absorption. There are many advantages to use this system. The slow dissolving ODC with B12 in the capsule matrix is filled with cocoa and sugar. It means, along with vitamin B12, the sweetened chocolate is released providing a great after meal satisfaction. It is possible to fill some other drug in the core of the capsule; mainly those drugs which cause B12 deficiency. One can also deliver even a size 000 capsule as it does not have to be swallowed but it dissolves in the mouth cavity.