Manufacturing and Bioprocessing
2019 PharmSci 360
3D printing is an emerging technology that is well suited to produce precision (personalized) medicine. It has a high potential for individualization of drug therapy combination through Polypills by which all the drugs required for the therapy can be printed into a single dosage unit. This presentation will highlight a case study of manufacturing a cardiovascular polypill of extended release Metoprolol (MT) and immediate release Atorvastatin (AT) using 3D pneumatic assisted micro-extrusion (PAM) technique. The effect of printing, geometrical and formulation parameters on breaking strength, disintegration of the polypills and release properties of the drugs will be discussed. Various designs of the polypills will be demonstrated to modulate the release rate of the drugs from the polypills. The design spaces for formulating these polypills will be discussed in terms of identifying the critical material attributes and key geometrical parameters that achieve independent release properties of both drugs from the polypills.