Formulation and Quality – Chemical
2019 PharmSci 360
Over the past decade, abuse and misuse of opioids has emerged as a major public health concern. One potential way of addressing the opioid epidemic is through the development of abuse-deterrent formulations (ADFs) which make certain types of abuse more difficult or less rewarding. Several ADFs utilize a polyethylene oxide (PEO) matrix to make the tablets more difficult to solubilize or crush which may discourage abuse through injection and insufflation. However, abuse by these routes may still be possible if the products are thermally treated or if that tablets are physically manipulated by grinding the tablets into a powder prior to solvent extraction. In the present study, the effect of physical manipulation and thermal treatment on the abuse deterrent properties was investigated. The results of this study will improve how ADFs are evaluated for abuse via the injection and insufflation routes.