Formulation and Quality
2019 PharmSci 360
Previous in vitro studies with model membranes (i.e. Strat-M®) and swine skin suggest that cocoyl caprylocaprate, isopropyl myristate and octyldodecanol might be able to enhance the penetration of some common topical drugs. To validate these observations, in vitro permeation studies (IVPT with Franz cells) through human skin were conducted with topical semi-solid creams containing cocoyl caprylocaprate (Kollicream® 3C), isopropyl myristate (Kollicream® IPM), octyldodecanol (Kollicream® OD), oleyl alcohol (Kollicream® OA), or mineral oil. Each of these excipients was formulated into individual creams that contained three different APIs with different polarities; Azelaic acid (Log P = 1.33), Metronidazole (Log P = -0.013) or Lidocaine HCl (Log P = 0.9). This presentation will report the effect of the different lipid-based excipients on the skin permeation of each of the three APIs and compare against a most widely used oil in topical formulations (mineral oil).