Formulation and Quality – Chemical
2019 PharmSci 360
The talk will describe a radiotherapeutic nanoparticle system that predominantly accumulates in peritoneal metastatic tumors upon intraperitoneal delivery. The radiation delivered induces deep tumor penetration of the nanoparticles. The tumor-specific radiation therapy significantly improves the median survival and ascites free survival of mice with peritoneal metastases. The presentation could trigger a discussion among the audience that would help close the gap in understanding how peritoneal tumors can be specifically targeted by intraperitoneal administration of nanotherapeutics, and how their penetration into deep tumor tissues is enhanced by radiation.