Clinical Pharmacology – Chemical
2019 PharmSci 360
The diagnosis of a brain tumor is among the most feared of all forms of cancer. More than 85% of adults over 40 yr old diagnosed with glioblastoma, the most common and aggressive type of adult brain tumor, will succumb to their disease within 2 years. For children diagnosed with a brain tumor, current contemporary therapy consisting of gross total resection followed by craniospinal irradiation and drug therapy, has led to a 5-year survival rate of 60 to 70%, but 30 to 40% of children with high risk tumors and those with recurrent tumors generally have a poor prognosis. Since drug therapy is one aspect of contemporary therapy for children with cancer, developing an improved understanding of drug delivery to tumors will likely lead to further therapeutic advances. In this presentation, the basic determinants associated with drug delivery to a tumor will be discussed including drug characteristics, physiological factors, and drug pharmacokinetics. Methods to study drug delivery will be considered including imaging, tumor measurements, and microdialysis. Lastly, during the presentation the unique challenges of a pediatric brain tumor will be briefly reviewed as well as opportunities to improve drug delivery to tumors.