Manufacturing and Bioprocessing – Chemical
2019 PharmSci 360
Terahertz instruments have been around for over a decade and at the outset GSK were one of the first pharmaceutical companies that invested in the technology. Over the years we have looked to use Terahertz Pulsed Imaging (TPI) in product development for products employing a functional coat and/or for troubleshooting. However, the number of products with a functional coat is a fraction of those compared to cosmetic coating, and issues with tablet coating in general can be typically be solved through process development and application of first principles thermodynamic models. Therefore, interest in terahertz has TPI waned. That is, until recently. External collaborations examining the application of transmission terahertz has renewed interest into the application as a Process Analytical Technology (PAT) tool for understanding tablet porosity and ultimately predicting dissolution.