Clinical Pharmacology – Biomolecular
2019 PharmSci 360
This presentation will uncover how prognostic factors can pose challenges to clinical pharmacology analyses. Particularly in oncology, prognostic factors can profoundly influence drug disposition and exposure-response relationships. Patient's health status can impact the pharmacokinetics of drugs that results in a complex time-dependent pharmacokinetic phenomenon. An imbalance in prognostic factors when subset by exposure may lead to false conclusions about the exposure-response relationships. This presentation will also discuss the mitigation strategies to overcome the confounding effects of prognostic factors in clinical pharmacology assessments.