Takeda Pharmaceuticals International Co. Cambridge, Massachusetts
The cases in this presentation demonstrate that in silico tools are powerful approaches to aid confirming the hypothesis, and guiding and optimizing the experimental design.
Modeling & simulation method with non-clinical (forward translation) and clinical data (reverse translation) enables safety switch control’s effective dose projection and inform in vitro experiments for better understanding killing mechanism and dose prediction.
In silico immunogenicity prediction can facilitate the selection of the relevant positive controls for cellular immunogenicity assays and potentially improve the sequence design to reduce the immunogenicity.
In silico approaches are powerful tools to optimize the experiemtal design.