Clinical Pharmacology – Chemical
2019 PharmSci 360
Ability to "predict" comes from understanding trends and patterns. Ability to discern trends and patterns relies on separation between "noise" (uncertainty) and "signal" (variation due to a co-variate). Whilst to "top-down" data analysis and "bottom-up" projections have had their own camps in the world of modelling and simulation, it is becoming clear that these two seemingly different philosophies are complementary to each other. The talk will provide an overview of the data analysis that is needed for reverse translation to obtain system parameters. These often combine in vitro in vivo extrapolation (IVIVE) with classical data analysis (e.g. non-linear mixed effect, epidemiological).