Formulation and Quality – Chemical
2019 PharmSci 360
Solubilization technologies enabled the recent hepatitis C treatment revolution including the commercialization of ZEPATIER®. This experience highlights both the impact and limitations in the application of solid solution technologies—particularly challenges associated with reducing pill burden and the development of fixed dose combination products. These challenges ultimately led to new understanding of how solid solution formulations can drive drug absorption under a variety of conditions including fasted, fed, and elevated stomach pH.