Category: Formulation and Quality
Purpose: The purpose of the present study is to describe and predict the deformation nature by using a set of commonly used mathematical equations and multivariate analysis based on continuous compression profile.
Methods: Tablets (10 mm diameter) of the excipients namely emcompress, emcocel, mannitol and starch 1500 were compressed with constant true volume at 50, 100, 150 MPa using compaction simulator (Presster). Data yielded a high repeatability and were evaluated by multivariate analysis (Principal component analysis (PCA) and Partial least squares (PLS) analysis).
Results: In-Die heckle plots, and work-related parameters were derived. Different material properties such as Yield pressure of plastic deformation (YPpl), yield pressure of elastic deformation (YPel), work of compression (WoC), work of elasticity (WoE) and tensile strength (TS) were studied. The PCA indicated that WoC and TS are negatively correlated to YPpl and YPel.
Conclusion: Mechanical parameters namely YPpl, YPel, WoC, WoE, Ejection force were estimated using continuous compression profile. Material predominant deformation nature was identified using qualitative analysis (PCA). Effect of deformation behavior on tablet tensile strength was estimated using quantitative regression analysis (PCR). It was observed that brittle materials are associated with high YPpl along with high YPel, plastic materials are associated with high WoC and elastic materials are associated with high WoE.