Category: Manufacturing and Bioprocessing
Purpose: There has been a growing interest in using 3D printing (3DP) for drug tablet manufacturing. This is motivated mainly by 3DP’s potential in achieving different dosage geometries, attaining complex drug release kinetics, and combining multiple drugs efficiently forpersonalized medicine applications. The aims of this study are to: (i) experimentally evaluate an inkjet-based 3D printing method for manufacturing of tablets, (ii) understand the underlying physics, and (iii) to compare against tablets produced by the conventional tableting process.
Methods: In an inkjet-based 3DP process, a liquid binder is printed onto a layer of excipient mixture to bind the powder in a pre-determined pattern. Then, a fresh layer of powder is then spread evenly on top, followed by another round of binder printing. The process is repeated until the construction of the 3D object, or drug tablet in this case, is finished. To achieve the aims of the study the following steps were taken-
Sameera Sansare– University of Connecticut School of Pharmacy, Storrs, Connecticut
Kavin Kowsari– Storrs, Connecticut
Anson Ma– Associate Professor, Institute of Material Sciences,Department of Chemical and Biomolecular Engineering, Storrs, Connecticut
Bodhi Chaudhuri– Associate Professor, University of Connecticut, Storrs, Connecticut