Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden U
Leiden, Zuid-Holland, Netherlands
Dr. Elizabeth de Lange is Professor in Predictive Pharmacology at the Leiden Academic Center for Drug Research (LACDR), Leiden University in Leiden (NL). Prof de Lange studied Biophysical Chemistry at the State University of Groningen (NL) and obtained her PhD at the LACDR on “The use of microdialysis to study blood-brain barrier transport characteristics of drugs”.
Her research focusses on the prediction of human drug kinetics and effects by translational pharmacokinetic -pharmacodynamic (PK-PD) model development, and understanding of the impact of disease conditions. These models are being developed on the basis of preclinical data, with particular emphasis on the Central Nervous System (CNS). Her research has a comparative and integrative design (mastermind approach) to elucidate conditional influences on individual mechanisms, and includes the cycle of simulations – predictions - experimental testing - data modeling – simulations etc. Experiments typically involve monitoring techniques in (freely moving) chronically instrumented animals. A highlight has been the development of the 9 compartment PBPK CNS model that allows prediction of CNS pharmacokinetic profiles in rat (CPT:PSP 2017) and human (EJPS 2019), on the basis of physico-chemical properties of small molecule drugs.
In 2013, she has been awarded AAPS fellow.
Tuesday, November 5
4:30 PM – 5:00 PM