Bioanalytics – Chemical
2019 PharmSci 360
Here we present optimized approaches for the LC-MS/MS bioanalysis of ADC’s, peptides and proteins. We will discuss the use of microflow LC-MS. We will discuss the importance of using ESI sources designed for microflow-LC-MS. We will also present how micro solid-phase extraction and immunocapture can be used for optimal analysis of peptides and proteins by LC-MS. Approaches for method development, validation and sample analysis will be described.