304 - Mechanistic Basis of Action and Resistance of B-lactam/B-lactamase Inhibitors

10/5/2019

3:15 PM - 4:30 PM

Room: Walter E. Washington Convention Center, Salon GHI

MOC Credit: Maximum of 1.25 hours of MOC Credit
CME Credit: Maximum of 1.25 hours of AMA PRA Category 1 Credit™
ACPE Credit: ACPE 1.25 knowledge-based contact hours of pharmacy CE
ACPE Number: 0221-9999-19-423-L01-P

Learning Objectives:

At the conclusion of this session, participants will be able to:

summarize the epidemiology of carbapenemase-producing organisms
identify mechanisms of resistance to newer BLBLIs
review recent advances in the development of inhibitors of metallo-beta-lactamases

Presentations:

3:15 PM - 3:40 PM
2873 - Genetic Basis of Carbapenemase Dissemination
Alessandra Carattoli, PhD – Sapienza University of Rome
3:40 PM - 4:05 PM
2874 - Inhibitors Against Metallo-Beta-Lactamases
Alejandro J. Vila, PhD – Instituto de Biología Molecular y Celular de Rosario (IBR)
4:05 PM - 4:30 PM
2875 - Avibactam and Vaborbactam Resistance
Ryan K. Shields, PharmD, MS – University of Pittsburgh

Moderator(s)

Yohei Doi, MD, PhD

Associate Professor of Medicine
University of Pittsburgh
Pittsburgh, Pennsylvania

Disclosure: Astellas: Grant/Research Support
Entasis: Advisory Board
Kanto Chemical: Grant/Research Support
MSD: Grant/Research Support, Other Financial or Material Support, Speaking Fee
Pfizer: Consultant, Grant/Research Support
Shionogi: Grant/Research Support, Speaking Fee
VenatoRx: Advisory Board
MM

Maria Mojica, PhD

Postdoctoral Scholar
Case Western Reserve University
Cleveland, OH

Disclosure: Nothing to disclose

Speaker(s)

AC

Alessandra Carattoli, PhD

Full Professor of Microbiology
Sapienza University of Rome
Rome, Italy

Disclosure: Nothing to disclose
Ryan Shields, PharmD, MS

Associate Professor of Medicine
University of Pittsburgh
Pittsburgh, PA

Disclosure: Allergan: Consultant, Grant/Research Support
Melinta Therapeutics: Grant/Research Support
Merck, Sharpe, and Dohme: Consultant, Grant/Research Support
Pfizer, Inc: Consultant
Shionogi: Consultant, Grant/Research Support
Tetraphase Pharmaceuticals: Grant/Research Support
VenatoRx: Grant/Research Support
AV

Alejandro Vila, PhD

Professor
Instituto de Biología Molecular y Celular de Rosario (IBR)
Rosario, Santa Fe, Argentina

Disclosure: Nothing to disclose