Adult ID

Investigative ID

Oral Abstract

182 - Emergent Mechanisms of Resistance and How to Prevent Them

Presentations:

• 1:45 PM - 2:00 PM

  1825 - Optimizing Beta-lactam Therapy in Surgical Intensive Care Unit Patients Using Therapeutic Drug Monitoring
  Mohammad H. Al-Shaer, PharmD – University of Florida; Eric Rubido – University of Florida; Daniel Lee – University of Florida; Kenneth Klinker, PharmD – University of Florida; Charles Peloquin, Pharm.D. – University of Florida
• 2:00 PM - 2:15 PM

  1826 - Impact of Rapid Diagnostics and Ceftazidime-Avibactam on Mortality after Bacteremia Caused by Carbapenem-Resistant Enterobacteriaceae
  Michael J. Satlin, MD, MS – Weill Cornell Medicine; Liang Chen, PhD – Center for Discovery and Innovation; Gregory Weston, MD MSCR – Montefiore Medical Center and Albert Einstein College of Medicine; Angela Gomez-Simmonds, MD – Columbia University Irving Medical Center; Tanaya Bhowmick, MD – Rutgers Robert Wood Johnson Medical School; Susan K. Seo, MD – Memorial Sloan Kettering; Steven Sperber, MD – Hackensack University Medical Center; Angela Kim, MD – Northwell Health; Brandon Eilertson, MD – State University of New York Downstate; Stephen Jenkins, PhD – Weill Cornell Medicine; Michael Levi, ScD – Albert Einstein College of Medicine; Anne-Catrin Uhlemann, MD, PhD – Columbia University Irving Medical Center; Melvin P. Weinstein, MD – Rutgers Robert Wood Johnson Medical School; Yi-Wei Tang, MD. Ph.D. – Memorial Sloan Kettering; Tao Hong, PhD – Hackensack University Medical Center; Stefan Juretschko, PhD – Northwell Health; Thomas J. Walsh, MD, PhD (hon) – Weill Cornell Medicine; Lars Westblade, PhD – Weill Cornell Medicine; Barry Kreiswirth, PhD – Center for Discovery and Innovation
• 2:15 PM - 2:30 PM

  1827 - Genetic Characterization of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates Associated with the Development of Reduced Susceptibility to Vancomycin from Latin America
  Monica Liliana Vargas Ardila, DVM – Universidad Nacional de Colombia; Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque; Betsy E. Castro-Cardozo, MSc – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia; Rafael Rios, MSc – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia; Angie K. Hernandez, BSc – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia; Lina V. Millan, MSc – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia; Lina P. Carvajal, PhD student – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia; Carlos Seas, MD – Universidad Peruana Cayetano Heredia; Jose M. Munita, MD – Genomics and Resistant Microbes (GeRM) Group. Millennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R); Cesar A. Arias, MD, MSc, PhD – University of Texas Health Science Center; Jinnethe Reyes, MSc, PhD – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia; Lorena Diaz, PhD – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
• 2:30 PM - 2:45 PM

  1828 - Bedaquiline Resistance in Mycobacterium intracellulare is Mediated by the Transcriptional Repressor MmpT5
  David Alexander, PHD – Cadham Provincial Laboratory; Joshua Yoneda – University of Regina; Supriya Bhat – University of Regina; Teagan Oleksyn – University of Saskatchwan; Jeffrey Chen, PHD – VIDO-InterVac; Cameron Andrew, PHD – University of Regina
• 2:45 PM - 3:00 PM

  1829 - The Paradox of KPC Bearing Strains of Klebsiella pneumoniae with the D179Y Substitution: Resistance to Ceftazidine/Avibactam (CZA) and Susceptibilty to Meropenem (MEM)
  Melissa D. Barnes, Ph.D. – Case Western Reserve University; Magdalena A. Taracilla, MS – Research Service, Louis Stokes Veterans Affairs Medical Center; Joseph D. Rutter, BS – Louis Stokes Cleveland VA Medical Center; Minh-Hong Nguyen, MD – University of Pittsburgh; Ryan K. Shields, PharmD, MS – University of Pittsburgh; Cornelius J. Clancy, MD – University of Pittsburgh; Robert A. Bonomo, MD – Louis Stokes Cleveland VA Medical Center

Co-Author(s)

• MB

  Melissa Barnes, Ph.D.

  Senior Research Associate
  Case Western Reserve University
  Cleveland, OH
• BC

  Betsy E. Castro-Cardozo, MSc

  Bacteriologist
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• LC

  Liang Chen, PhD

  Dr
  Center for Discovery and Innovation
  Nutley, NJ

  Disclosure: Nothing to disclose
• ER

  Eric Rubido

  PharmD student
  University of Florida
  Gainesville, FL

  Disclosure: Nothing to disclose
• MT

  Magdalena Taracilla, MS

  Researcher
  Research Service, Louis Stokes Veterans Affairs Medical Center
  Cleveland, OH

  Disclosure: Nothing to disclose
• JY

  Joshua Yoneda

  Student
  University of Regina
  Regina, SK, Canada

  Disclosure: Nothing to disclose
• SB

  Supriya Bhat

  Student
  University of Regina
  Regina, SK, Canada

  Disclosure: Nothing to disclose
• DL

  Daniel Lee

  PharmD student
  University of Florida
  Gainesville, FL

  Disclosure: Nothing to disclose
• RR

  Rafael Rios, MSc

  Bioinformatician
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• JR

  Joseph Rutter, BS

  Research Assistant
  Louis Stokes Cleveland VA Medical Center
  Cleveland, OH

  Disclosure: Nothing to disclose
• GW

  Gregory Weston, MD MSCR

  Assistant Professor
  Montefiore Medical Center and Albert Einstein College of Medicine
  Bronx, New York

  Disclosure: Nothing to disclose
• AG

  Angela Gomez-Simmonds, MD

  Instructor
  Columbia University Irving Medical Center
  New York, NY

  Disclosure: Nothing to disclose
• AH

  Angie K. Hernandez, BSc

  Research fellow
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• KK

  Kenneth Klinker, PharmD

  Associate Professor
  University of Florida
  Gainesville, FL

  Disclosure: Merck & Co., Inc., Kenilworth, NJ: Employee
• MN

  Minh-Hong Nguyen, MD

  Professor of Medicine
  University of Pittsburgh
  Pittsburgh, PA

  Disclosure: Astellas: Consultant, Grant/Research Support
  Cidara: Consultant, Grant/Research Support
  Melinta: Grant/Research Support
  Merck: Consultant, Grant/Research Support
  Scynexis: Consultant
• TO

  Teagan Oleksyn

  Student
  University of Saskatchwan
  Saskatoon, SK, Canada

  Disclosure: Nothing to disclose
• TB

  Tanaya Bhowmick, MD

  Assistant Professor
  Rutgers Robert Wood Johnson Medical School
  New Brunswick, NJ

  Disclosure: Nothing to disclose
• JC

  Jeffrey Chen, PHD

  Research Scientist II / Principal Investigator
  VIDO-InterVac
  Saskatoon, SK, Canada

  Disclosure: Nothing to disclose
• LM

  Lina V. Millan, MSc

  Research fellow
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• CP

  Charles Peloquin, Pharm.D.

  Professor and Director, Infectious Disease Pharmacokinetics Laboratory
  University of Florida
  Gainesville, FL

  Disclosure: Nothing to disclose
• 

  Ryan Shields, PharmD, MS

  Associate Professor of Medicine
  University of Pittsburgh
  Pittsburgh, PA

  Disclosure: Allergan: Consultant, Grant/Research Support
  Melinta Therapeutics: Grant/Research Support
  Merck, Sharpe, and Dohme: Consultant, Grant/Research Support
  Pfizer, Inc: Consultant
  Shionogi: Consultant, Grant/Research Support
  Tetraphase Pharmaceuticals: Grant/Research Support
  VenatoRx: Grant/Research Support
• CA

  Cameron Andrew, PHD

  Associate Professor
  University of Regina
  Regina, SK, Canada

  Disclosure: Nothing to disclose
• LC

  Lina P. Carvajal, PhD student

  Assistant Professor
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• CC

  Cornelius Clancy, MD

  Associate Professor of Medicine
  University of Pittsburgh
  Pittsburgh, PA

  Disclosure: Astellas: Consultant, Grant/Research Support
  Cidara: Consultant, Research Grant or Support
  Melinta: Grant/Research Support
  Merck: Consultant, Grant/Research Support
  Needham Associates: Consultant
  Qpex: Consultant
  Scynexis: Consultant
  Shionogi: Consultant
• SS

  Susan Seo, MD

  Director, Antibiotic Management Program
  Memorial Sloan Kettering
  New York, New York

  Disclosure: Nothing to disclose
• 

  Carlos Seas, MD

  Doctor of Medicine
  Universidad Peruana Cayetano Heredia
  Lima, Lima, Peru

  Disclosure: Nothing to disclose
• SS

  Steven Sperber, MD

  Division Chief of Infectious Diseases
  Hackensack University Medical Center
  Hackensack, NJ

  Disclosure: Nothing to disclose
• AK

  Angela Kim, MD

  Associate Director
  Northwell Health
  Manhasset, NY

  Disclosure: Nothing to disclose
• 

  Jose Munita, MD

  Associate Professor
  Genomics and Resistant Microbes (GeRM) Group. Millennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R)
  Santiago, Region Metropolitana, Chile

  Disclosure: Biomerieux: Grant/Research Support
  Merck, Sharpe, and Dohme: Grant/Research Support
  Pfizer: Grant/Research Support
• 

  Cesar Arias, MD, MSc, PhD

  Professor
  University of Texas Health Science Center
  Houston, TX

  Disclosure: American Society for Microbiology: Fees for Editor of Antimicrobial Agents and Chemotherapy. Money paid to University, Other Financial or Material Support
  Entasis Pharmaceuticals: Grant/Research Support, Research Grant
  MeMed Diagnostics: Grant/Research Support, Research Grant
  Merck: Grant/Research Support, Research Grant
  UptoDate: Other Financial or Material Support, Royalties from a Chapter
• BE

  Brandon Eilertson, MD

  Assistant Professor
  State University of New York Downstate
  New York, NY

  Disclosure: Nothing to disclose
• SJ

  Stephen Jenkins, PhD

  Professor
  Weill Cornell Medicine
  New York, NY

  Disclosure: Merck: Grant/Research Support
• JR

  Jinnethe Reyes, MSc, PhD

  Postdoctoral fellow
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• LD

  Lorena Diaz, PhD

  Postdoctoral fellow
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• ML

  Michael Levi, ScD

  Associate Professor
  Albert Einstein College of Medicine
  Bronx, NY

  Disclosure: Nothing to disclose
• AU

  Anne-Catrin Uhlemann, MD, PhD

  Associate Professor
  Columbia University Irving Medical Center
  New York, New York

  Disclosure: Nothing to disclose
• MW

  Melvin Weinstein, MD

  Professor of Medicine and Pathology & Laboratory Medicine
  Rutgers Robert Wood Johnson Medical School
  New Brunswick, New Jersey

  Disclosure: Nothing to disclose
• YT

  Yi-Wei Tang, MD. Ph.D.

  Attending
  Memorial Sloan Kettering
  New York, NY

  Disclosure: Nothing to disclose
• TH

  Tao Hong, PhD

  Chief of Microbiology and Molecular Diagnostics
  Hackensack University Medical Center
  Hackensack, NJ

  Disclosure: Nothing to disclose
• SJ

  Stefan Juretschko, PhD

  Director, Division of Infectious Disease Diagnostics
  Northwell Health
  Lake Success, NY

  Disclosure: Nothing to disclose
• TW

  Thomas Walsh, MD, PhD (hon)

  Professor
  Weill Cornell Medicine
  New York, NY

  Disclosure: Astellas Pharma, Inc.: Other Financial or Material Support, This study was initiated and sponsored by Astellas
  Astellas Pharma, Inc.: Grant/Research Support
• LW

  Lars Westblade, PhD

  Associate Professor
  Weill Cornell Medicine
  New York, New York

  Disclosure: Allergan: Grant/Research Support
  Biofire Diagnostics: Grant/Research Support
• BK

  Barry Kreiswirth, PhD

  Dr
  Center for Discovery and Innovation
  Newark, NJ

  Disclosure: Nothing to disclose

Moderator(s)

• 

  Amy Mathers, MD, D(ABMM)

  Associate Professor
  University of Virginia
  Charlottesville, Virginia

  Disclosure: Accelerate Diagnostics: Consultant
  Antimicrobial Resistance Services: Consultant
  SeLux Diagnostics: Consultant, Research Grant
  VenatoRx: Advisory Board
• 

  Samuel Aitken, PharmD, MPH, BCIDP

  Clinical Pharmacy Specialist - Infectious Diseases
  The University of Texas MD Anderson Cancer Center
  Houston, Texas

  Disclosure: Melinta Therapeutoics: Grant/Research Support, Research Grant
  Merck, Sharpe, and Dohme: Advisory Board
  Shionogi: Advisory Board

Presenting Author(s)

• DA

  David Alexander, PHD

  Scientist
  Cadham Provincial Laboratory
  Winnipeg, MB, Canada

  Disclosure: Nothing to disclose
• MA

  Mohammad Al-Shaer, PharmD

  Graduate assistant
  University of Florida
  Gainesville, FL

  Disclosure: Nothing to disclose
• MS

  Michael Satlin, MD, MS

  Assistant Professor
  Weill Cornell Medicine
  New York, NY

  Disclosure: Achaogen: Consultant
  Allergan: Grant/Research Support
  Biofire Diagnostics: Grant/Research Support
  Merck: Grant/Research Support
  Shionogi: Consultant
• MV

  Monica Liliana Vargas Ardila, DVM

  Doctor of Veterinary Medicine
  Universidad Nacional de Colombia; Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: Nothing to disclose
• RB

  Robert Bonomo, MD

  Chief of Medicine
  Louis Stokes Cleveland VA Medical Center
  Cleveland, Ohio

  Disclosure: Nothing to disclose